9AZQ

INF2 at the Barbed End of F-Actin with Incoming Actin

PDB DOI: https://doi.org/10.2210/pdb9AZQ/pdb
EM Map EMD-44019: EMDB EMDataResource

Classification: CYTOSOLIC PROTEIN
Organism(s): Oryctolagus cuniculus, Homo sapiens
Expression System: Oryctolagus cuniculus, Escherichia coli
Mutation(s): No

Deposited: 2024-03-11 Released: 2024-05-29
Deposition Author(s): Palmer, N.J., Barrie, K.R., Dominguez, R.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Experimental Data Snapshot

Method: ELECTRON MICROSCOPY
Resolution: 3.82 Å
Aggregation State: PARTICLE
Reconstruction Method: SINGLE PARTICLE

wwPDB Validation 3D Report Full Report

This is version 1.0 of the entry. See complete history.

Literature

Mechanisms of Actin Filament Severing and Elongation by Formins

Palmer, N.J., Barrie, K.R., Dominguez, R.

To be published.

Macromolecule Content

Total Structure Weight: 336.6 kDa
Atom Count: 23,563
Modelled Residue Count: 2,980
Deposited Residue Count: 2,980
Unique protein chains: 3

Macromolecules

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(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Actin, alpha skeletal muscle	A, B, C, D, E A, B, C, D, E, F, I	371	Oryctolagus cuniculus	Mutation(s): 0 Gene Names: ACTA1, ACTA EC: 3.6.4
UniProt
Find proteins for P68135 (Oryctolagus cuniculus) Explore P68135 Go to UniProtKB: P68135
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P68135
Sequence Annotations Expand
Reference Sequence

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(by identity cutoff) | 3D Structure

Entity ID: 2
Molecule	Chains	Sequence Length	Organism	Details	Image
Inverted formin-2	G	60	Homo sapiens	Mutation(s): 0 Gene Names: INF2, C14orf151, C14orf173
UniProt & NIH Common Fund Data Resources
Find proteins for Q27J81 (Homo sapiens) Explore Q27J81 Go to UniProtKB: Q27J81
PHAROS: Q27J81 GTEx: ENSG00000203485
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q27J81
Sequence Annotations Expand
Reference Sequence

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 3
Molecule	Chains	Sequence Length	Organism	Details	Image
Inverted formin-2	H	323	Homo sapiens	Mutation(s): 0 Gene Names: INF2, C14orf151, C14orf173
UniProt & NIH Common Fund Data Resources
Find proteins for Q27J81 (Homo sapiens) Explore Q27J81 Go to UniProtKB: Q27J81
PHAROS: Q27J81 GTEx: ENSG00000203485
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q27J81
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 2 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
ADP Query on ADP Download Ideal Coordinates CCD File SDF format, chain J [auth A] SDF format, chain L [auth B] SDF format, chain N [auth C] SDF format, chain P [auth D] SDF format, chain R [auth E] SDF format, chain T [auth F] SDF format, chain V [auth I] MOL2 format, chain J [auth A] MOL2 format, chain L [auth B] MOL2 format, chain N [auth C] MOL2 format, chain P [auth D] MOL2 format, chain R [auth E] MOL2 format, chain T [auth F] MOL2 format, chain V [auth I]	J [auth A] L [auth B] N [auth C] P [auth D] R [auth E] J [auth A], L [auth B], N [auth C], P [auth D], R [auth E], T [auth F], V [auth I]	ADENOSINE-5'-DIPHOSPHATE C₁₀ H₁₅ N₅ O₁₀ P₂ XTWYTFMLZFPYCI-KQYNXXCUSA-N		Interactions Focus chain J [auth A] Focus chain L [auth B] Focus chain N [auth C] Focus chain P [auth D] Focus chain R [auth E] Focus chain T [auth F] Focus chain V [auth I] Interactions & Density Focus chain J [auth A] Focus chain L [auth B] Focus chain N [auth C] Focus chain P [auth D] Focus chain R [auth E] Focus chain T [auth F] Focus chain V [auth I]
MG Query on MG Download Ideal Coordinates CCD File SDF format, chain K [auth A] SDF format, chain M [auth B] SDF format, chain O [auth C] SDF format, chain Q [auth D] SDF format, chain S [auth E] SDF format, chain U [auth F] SDF format, chain W [auth I] MOL2 format, chain K [auth A] MOL2 format, chain M [auth B] MOL2 format, chain O [auth C] MOL2 format, chain Q [auth D] MOL2 format, chain S [auth E] MOL2 format, chain U [auth F] MOL2 format, chain W [auth I]	K [auth A] M [auth B] O [auth C] Q [auth D] S [auth E] K [auth A], M [auth B], O [auth C], Q [auth D], S [auth E], U [auth F], W [auth I]	MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N		Interactions Focus chain K [auth A] Focus chain M [auth B] Focus chain O [auth C] Focus chain Q [auth D] Focus chain S [auth E] Focus chain U [auth F] Focus chain W [auth I] Interactions & Density Focus chain K [auth A] Focus chain M [auth B] Focus chain O [auth C] Focus chain Q [auth D] Focus chain S [auth E] Focus chain U [auth F] Focus chain W [auth I]