HIS

HISTIDINE

Find entries where: HIS

is present as a standalone ligand in 99 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 7 entries

is present in a polymer sequence 207,734 entries

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Chemical Component Summary
Name	HISTIDINE
Identifiers	(2S)-2-amino-3-(1H-imidazol-3-ium-4-yl)propanoic acid
Formula	C₆ H₁₀ N₃ O₂
Molecular Weight	156.162
Type	L-PEPTIDE LINKING
Isomeric SMILES	c1c([nH+]c[nH]1)C[C@@H](C(=O)O)N
InChI	InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/p+1/t5-/m0/s1
InChIKey	HNDVDQJCIGZPNO-YFKPBYRVSA-O

Chemical Details
Formal Charge	1
Atom Count	21
Chiral Atom Count	1
Bond Count	21
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB00117
Name	Histidine
Groups	investigational nutraceutical
Description	An essential amino acid that is required for the production of histamine.
Synonyms	Copper histidine L-Histidin (S)-4-(2-Amino-2-carboxyethyl)imidazole Histidine monohydrochloride monohydrate (S)-alpha-Amino-1H-imidazole-4-propionic acid Histidina Histidine (S)-alpha-amino-1H-Imidazole-4-propanoic acid L-Histidine L-(−)-histidine HIS (S)-a-Amino-1H-imidazole-4-propanoic acid (S)-α-amino-1H-Imidazole-4-propanoic acid
Brand Names	20% Prosol Aminosyn-PF Nutrineal Pd4 Travasol Inj Without Electrolytes 5.5% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. RenAmin Vamin N NephrAmine ProSol Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Aminosyn Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Vamin 18 Electrolyte-free Aminosyn HF CAREDO Treating Periodontitis Toothpastes 100g Renamin (amino Acids) Injection Nephramine Liq IV Perikabiven Aminosyn II 7% Injection 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II and Dextrose Aminosyn-PF 7% Travasol Amino Acid Inj 8.5% Travasol E ProcalAmine Aminosyn II 8.5% With 50% Dextrose Primene 10%-liq IV 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II In Dextrose Injection Aminosyn RF Injection Kabiven Olimel 7.6% FreAmine III Smofkabiven Extra Nitrogen Electrolyte Free 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II with Electrolytes Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn 7% 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Clinisol Premasol - sulfite-free (Amino Acid) Aminosyn II with Electrolytes in Dextrose with Calcium 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Smofkabiven Electrolyte Free Olimel 5.7% E 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Plenamine 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Travasol Inj Without Electrolytes 8.5% 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Olimel 3.3% E Olimel 7.6% E Essepna 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Aminosyn 8.5% Primene 10% Aminosyn II 7% M In 10% Dextrose(dual Chamber) 2.75% Travas. Amino Acid InJ.W.elecw.25%dex 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose FreAmine HBC Olimel 4.4% E 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Aminosyn 8.5% Injection With Electrolytes 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex. TrophAmine Smofkabiven Clinimix 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Travasol Aminosyn II 7% With 50% Dextrose 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Primene 8.5% Freamine III Aminosyn 5% Aminosyn 10% W Electrolytes Aminosyn II 5% Inj Synthamin Trepoxen-250 Hepatasol Aminosyn II 7% With 10% Dextrose HepatAmine Smofkabiven Peripheral 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn RF Novamine Clinimix E Olimel 4.4% Travasol Amino Acid Inj 5.5% Periolimel 2.5% E Aminosyn II 8.5% Injection Aminosyn II in Dextrose Trepoxicam-7.5 Aminosyn II 10% With Electrolytes Smofkabiven Extra Nitrogen Olimel 5.7% Aminosyn-PF 10% Aminosyn II Aminosyn Sulfite Free Aminosyn 3.5% M
Indication	The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
Categories	Amino Acids Amino Acids, Cyclic Amino Acids, Essential Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	71-00-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Histidine decarboxylase	MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPED...	unknown
Histidine--tRNA ligase, cytoplasmic	MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDES...	unknown
Sodium-coupled neutral amino acid transporter 3	MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQ...	unknown
Histidine ammonia-lyase	MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDD...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682